Alectinib ± Upfront Radiosurgery

600mg taken orally, twice daily for 25 Cycles Cycle = 4 weeks (28 days)

SRS dose varies by brain met size and location

This study will consist of a Phase 1b and Phase 2 portion. The Phase 1b portion will enroll first followed by the Phase 2 portion. Each cycle of treatment = 28 days. Subjects will receive alectinib twice daily. Those in the Phase 1b portion will receive alectinib alone. Those in Phase 2 Arm A will receive alectinib alone. Those in Phase 2, Arm B will receive SRS + alectinib. A maximum of 25 cycles (2 years) of alectinib may be administered on study.

Registro actualizado en ClinicalTrials.gov →

• Written informed consent and HIPAA authorization for release of personal health information prior to registration. NOTE: HIPAA authorization may be included in the informed consent or obtained separately.
• Age ≥ 18 years at the time of consent.
• Fluent English skills with comprehensive/speaking skills equal to those of a native English speaker as assessed by the site investigator.
• ECOG Performance Status of ≤ 2 within 14 days prior to registration.

Criterios de inclusión tal como figuran en el registro, recortados. La lista completa, con las exclusiones, está en el registro actualizado.