TriangleAlectinib ± Radiosurgery (NCT05987644)
Alectinib ± Radiosurgery trial for ALK-Positive Lung Cancer With Brain Metastases (NCT05987644). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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This trial is for adults with ALK positive lung cancer that has spread to the brain, with few or no symptoms, who have not been treated yet.
The idea: alectinib is a twice daily pill that targets ALK and can reach the brain. The question is whether brain radiation can wait. In the phase 2 part, one group takes alectinib alone, and another gets stereotactic radiosurgery, a focused high dose of radiation, plus alectinib.
This phase 1 and 2 study plans 56 patients. At Ohio State University Comprehensive Cancer Center in Columbus, Joshua Palmer leads it.
Public record; not medical advice.
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