STARLITE

Participants will take one 600mg tablet of Abacavir orally once daily, as part of combination antiretroviral therapy (ART).

Participants will take one 300mg tablet of Lamivudine orally once daily, as part of combination antiretroviral therapy (ART)

The purpose of this study is to determine whether newly diagnosed high-grade glioma(s) that cannot be removed surgically change as a result of the study treatment; and to identify and evaluate the potential side effects (good and bad) of the study treatment in patients with newly diagnosed high-grade glioma(s) that cannot be removed surgically.

Live record on ClinicalTrials.gov →

• Patients with a histologically confirmed or suspected high-grade glioma (HGG) by MRI.
• a. For cases with suspected HGG, intraoperative frozen section diagnoses of HGG must be made by pathologists (Section 4.4.1).
• Uni-focal or butterfly gliomas that can receive ≥70% of lesion volume ablated as determined by the treating surgeon.
• Gliomas must be located or positioned where surgical resection is either not feasible or high-risk as deemed by a group of surgical neuro-oncologists.
• Preoperative Karnofsky score ≥ 70 (APPENDIX A).
• Patients must have demonstrable normal organ function as defined below within 14 days of surgery.

Inclusion criteria as written on the registry, trimmed. The full list, with exclusions, is on the live record.