24 Phase 1 studies recruiting right now, most recently updated first.
Brain and CNS24 studies
Currently Only Enrolling Glioblastoma Patients at First RecurrenceNCT05139056
Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas
Recurrent GliosarcomaNCT04991870
Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM
Neoplasms, BrainNCT03911388Papers
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
Central Nervous System NeoplasmsNCT07390539
B7-H3.CD28Z.CART in CNS Neoplasms
Recurrent GlioblastomaNCT07579208
Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent Glioblastoma
Newly Diagnosed GlioblastomaNCT04903795
BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma
Diffuse Intrinsic Pontine GliomaNCT04099797Papers
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
High Grade GliomaNCT05278208Papers
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors
Recurrent GlioblastomaNCT03896568Papers
MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma
GlioblastomaNCT05660369Papers
CARv3-TEAM-E T Cells in Glioblastoma
Recurrent GlioblastomaNCT06815029
Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma
Adult GlioblastomaNCT04573140Papers
RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)
Medulloblastoma, ChildhoodNCT06193759
Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)
Recurrent Diffuse Hemispheric Glioma, H3 G34-MutantNCT06914479
Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors
Brain Tumor, RecurrentNCT06666712Papers
Chronic CED of TPT for Recurrent Malignant Glioma
Glioblastoma (GBM)NCT07346144Papers
An AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma
Glioblastoma MultiformeNCT01269853Papers
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA
Recurrent Malignant GliomaNCT06964737Papers
Anti-GARP Chimeric Antigen Receptor T Cell Therapy for the Treatment of Recurrent Grade III or IV Gliomas
Pediatric Recurrent Central Nervous System TumorsNCT03988283
Neoepitope-based Personalized DNA Vaccine Approach in Pediatric Patients With Recurrent Central Nervous System Tumors
Central Nervous System TumorNCT04185038Papers
B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Malignant Brain NeoplasmNCT04510051Papers
CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children
Solid Tumor (Excluding CNS)NCT07148050
Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells
Glioma of Spinal CordNCT04196413Papers
GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG)
Malignant Glioma of BrainNCT05686798Papers
Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma
Triangle