TriangleRelapsed/Refractory DLL3-Expressing TumorsNCT06814496
Tarlatamab + Radiation Therapy
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
Subjects will receive monthly dosing of bevacizumab (15 mg/kg) and cetuximab (200mg/m2)
SIACI of cetuximab and bevacizumab
Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age
- RegistryNCT05956821
- PhasePhase 1/2
- StatusRecruiting
- ConditionRelapsed/Refractory Intracranial Glioma
- SponsorUniversity of Miami
The drug
What is being tested.
The study
How the trial runs.
This study assesses the safety and efficacy of repeat monthly dosing of super-selective intra-arterial cerebral infusion (SIACI) of cetuximab and bevacizumab in patients < 22 years of age.
Eligibility
Who the study is looking for.
- Documented histologic diagnosis of relapsed or refractory glioblastoma multiforme (GBM), anaplastic astrocytoma (AA), fibrillary astrocytomas (FA), pilomyxoid astrocytoma (PXA), oligodendroglioma, or anaplastic mixed oligoastrocytoma (AOA), or radiologically diagnosed diffuse intrinsic brainstem glioma (DIPG)
- Must have at least one confirmed and evaluable tumor site
- Must have a Karnofsky or Lansky performance status ≥60%.
- No chemotherapy for three weeks prior to treatment
- Patients must have adequate hematologic reserve with absolute neutrophils≥1000/mm3 and platelets ≥100,000/ mm3
- Pre-enrollment chemistry parameters must show: bilirubin<1.5x the institutional upper limit of normal (IUNL); Aspartate Aminotransferase( AST) or Alanine transaminase (ALT)<2.5x IUNL and creatinine<1.5x IUNL
Inclusion criteria as written on the registry, trimmed. The full list, with exclusions, is on the live record.
For you, or someone you love
Whether or not this trial is the one, bring AI into your corner.
A complex diagnosis brings new questions every week, in a trial and out of one. Triangle keeps your whole medical file together, reads it with you in plain language, and helps you and your family decide what to ask next.
Start your 7-day free trial
Then $9 a month. Cancel anytime.
Every record in one place
Requested from your hospitals and clinics through the national networks. Add scans, pathology and anything on paper.
Read in plain words
Reports explained as they come in, with lab values you can follow before treatment, during a trial and after.
Ready for every appointment
Ask about your own file, and walk in with questions for your oncologist or the trial team.
Your people, in the loop
Share one profile with the family helping you, and with your doctors.
Members also get a deeper analysis of their records and any sequencing data, including clinical trials that may fit, reviewed by a licensed physician before they receive it.
How these trials work: what Phase 1 actually is · common questions Not clinical evidence.
Not sure whether you would qualify?
Would this trial apply to me?7-day free trial, then $9 a month. Cancel anytime.