Triangle(RIOT 4A) (NCT07192900)
(RIOT 4A) trial for Malignant Pleural Effusion (NCT07192900). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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When cancer reaches the lining of the lung, fluid collects and breathing gets harder. Drained through a catheter, that fluid is usually discarded.
The idea: that fluid is full of the patient's own T cells that already found the tumor. Grow them, and put them back.
At West Penn Hospital in Pittsburgh, the fluid goes to an on-site lab and its T cells are expanded over days, not weeks. After outpatient chemotherapy makes room, the cells return through the same catheter, with two days of low-dose interleukin-2 given locally, so the rest of the body sees little.
RIOT 4A is a first study in people, for pleural metastases or mesothelioma after standard treatment fails. David Bartlett leads it. Public record; not medical advice.
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