Triangle(RIOT 4A) (NCT07192900)
(RIOT 4A) trial for Malignant Pleural Effusion (NCT07192900). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
When cancer reaches the lining of the lung, fluid collects and breathing gets harder. Drained through a catheter, that fluid is usually discarded.
The idea: that fluid is full of the patient's own T cells that already found the tumor. Grow them, and put them back.
At West Penn Hospital in Pittsburgh, the fluid goes to an on-site lab and its T cells are expanded over days, not weeks. After outpatient chemotherapy makes room, the cells return through the same catheter, with two days of low-dose interleukin-2 given locally, so the rest of the body sees little.
RIOT 4A is a first study in people, for pleural metastases or mesothelioma after standard treatment fails. David Bartlett leads it. Public record; not medical advice.
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How these trials work: what Phase 1 actually is · common questions Not clinical evidence.