DC/MM Fusion Vaccine

Dendritic Cell and tumor fusion vaccine, via subcutaneous injection (under the skin), per protocol.

Granulocyte-Macrophage Colony-Stimulating Factor, via subcutaneous injection, per standard of care.

This Phase I study is to evaluate the safety and effectiveness of dendritic cell DC/MM fusion vaccine in combination with standard of care B-cell maturation antigen (BCMA) CAR-T cell therapy in participants with relapsed/refractory multiple myeloma. The DC/MM fusion vaccine is an investigational agent that tries to help the immune system to recognize and fight against cancer cells. The U.S.

This study is to evaluate the safety and effectiveness of dendritic cell DC/MM fusion vaccine in combination with standard of care B-cell maturation antigen (BCMA) CAR-T cell therapy in participants with relapsed/refractory multiple myeloma. The names of the study drugs involved in this study are: * DC/MM fusion vaccine (a type of personalized cancer vaccine) * Granulocyte-macrophage colony-stimulating factor (GM-CSF) (a type of growth factor or hormone)

Registro actualizado en ClinicalTrials.gov →

• Patients must be eligible to receive standard of care CAR T-cell therapy for relapsed or refractory multiple myeloma
• Patients must be ≥18 years of age
• Estado funcional del Eastern Cooperative Oncology Group (ECOG) ≤ 2
• Patients must have 20% or more plasma cells in the bone marrow core or aspirate differential within 30 days prior to enrollment.
• Total bilirubin ≤ 1.5 x institutional upper limit of normal

Criterios de inclusión tal como figuran en el registro, recortados. La lista completa, con las exclusiones, está en el registro actualizado.