TriangleC7R-GD2.CART cells (IV and ICV… (NCT04099797)
C7R-GD2.CART cells (IV and ICV infusion) trial for Diffuse Intrinsic Pontine Glioma (NCT04099797). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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The deadliest childhood brain tumors, diffuse midline gliomas, carry a surface molecule called GD2. Immune cells engineered to hunt GD2 can find them, but they tire and fade before the job is done.
The idea: give the hunters a built-in supply of the signal that keeps T cells alive.
A child's own T cells get two genes. One is a receptor for GD2. The other, C7R, is a permanently switched-on receptor for interleukin-7, the survival signal T cells normally need from outside.
In the first eleven children there were no dose-limiting side effects, and two of seven gliomas shrank.
GAIL-B, at Texas Children's with Jasia Mahdi and Bilal Omer, now gives the cells into the fluid around the brain. Public record; not medical advice.
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