TriangleC7R-GD2.CART cells (IV and ICV… (NCT04099797)
C7R-GD2.CART cells (IV and ICV infusion) trial for Diffuse Intrinsic Pontine Glioma (NCT04099797). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
The deadliest childhood brain tumors, diffuse midline gliomas, carry a surface molecule called GD2. Immune cells engineered to hunt GD2 can find them, but they tire and fade before the job is done.
The idea: give the hunters a built-in supply of the signal that keeps T cells alive.
A child's own T cells get two genes. One is a receptor for GD2. The other, C7R, is a permanently switched-on receptor for interleukin-7, the survival signal T cells normally need from outside.
In the first eleven children there were no dose-limiting side effects, and two of seven gliomas shrank.
GAIL-B, at Texas Children's with Jasia Mahdi and Bilal Omer, now gives the cells into the fluid around the brain. Public record; not medical advice.
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