TriangleTROP2 CAR/IL-15 TGFBR2 KO NK Cells (NCT07509008)
TROP2 CAR/IL-15 TGFBR2 KO NK Cells trial for Gastric Cancer, Metastatic (NCT07509008). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for stomach cancer that has spread to the peritoneum, the lining of the abdomen.
The idea: put the treatment where the cancer is. Natural killer cells, immune cells from donated cord blood, are engineered to recognize TROP2 and to carry the signal IL-15. One more gene, for the TGF-beta receptor 2, is switched off.
After a minimally invasive staging surgery, the cells are infused straight into the abdomen through a port. The first question is safety and the best dose. At MD Anderson in Houston, Brian Badgwell leads this early study.
Public record; not medical advice.
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