TriangleTROP2 CAR/IL-15 TGFBR2 KO NK Cells (NCT07509008)
TROP2 CAR/IL-15 TGFBR2 KO NK Cells trial for Gastric Cancer, Metastatic (NCT07509008). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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This trial is for stomach cancer that has spread to the peritoneum, the lining of the abdomen.
The idea: put the treatment where the cancer is. Natural killer cells, immune cells from donated cord blood, are engineered to recognize TROP2 and to carry the signal IL-15. One more gene, for the TGF-beta receptor 2, is switched off.
After a minimally invasive staging surgery, the cells are infused straight into the abdomen through a port. The first question is safety and the best dose. At MD Anderson in Houston, Brian Badgwell leads this early study.
Public record; not medical advice.
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