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Chemoimmunotherapy + SFRT and… (NCT06546969)

How Chemoimmunotherapy + SFRT and Hyperthermia worksNCT065469691 min

Chemoimmunotherapy + SFRT and Hyperthermia trial for Advanced Biliary Tract Cancer (NCT06546969). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with advanced biliary tract cancer, including cholangiocarcinoma, who do not qualify for surgery.

The idea: add two treatments to standard chemoimmunotherapy with gemcitabine, cisplatin and durvalumab. One tumor gets a single dose of spatially fractionated radiation, then two sessions of deep hyperthermia, which heats the tumor.

This phase 1 study plans 15 patients and measures serious side effects and whether heating reaches its target. At the University of Maryland in Baltimore, Jason Molitoris leads it.

Public record; not medical advice.

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How these trials work: what Phase 1 actually is · common questions Not clinical evidence.