TriangleEarly-Stage Resectable Non-Small Cell Lung CancerNCT06566443Papers
Honokiol
Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer
500 mg/m2 day 1 of 21 day cycle (for non-squamous only)
100 mg/m2 days 1,8 of 21 day cycle x 4 cycles
Pembrolizumab + Single-Agent Chemotherapy
Pembrolizumab and Single Agent Chemotherapy as First Line Treatment for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer With Eastern Cooperative Oncology Group (ECOG) Performance Status of 2
- RegistryNCT04297605
- PhasePhase 1
- StatusRecruiting
- ConditionLocally Advanced or Metastatic Non-Small Cell Lung Cancer (ECOG 2)
- SponsorUniversity of Rochester
The drug
What is being tested.
The study
How the trial runs.
The purpose of this study is to understand if treatment with one chemotherapy medication combined with immune therapy (pembrolizumab) is tolerable and effective for patients with lung cancer and performance status of 2 (PS2), which means you have limitations in carrying out certain activities or spend up to half of your day resting.
Eligibility
Who the study is looking for.
- Participants must be >18 years old at time of diagnosis
- Histologically confirmed non-small cell lung cancer
- Clinical staging of IIIc or IV disease.
- 4A. For patients with stage IIIc disease, patients are ineligible for or refuse standard treatment with platinum-double chemotherapy and radiation.
- 4B. For patients with stage IV disease, platinum doublet chemotherapy is not appropriate, deemed unsafe by the treating physician, or declined by the patient
Inclusion criteria as written on the registry, trimmed. The full list, with exclusions, is on the live record.
For you, or someone you love
Whether or not this trial is the one, bring AI into your corner.
A complex diagnosis brings new questions every week, in a trial and out of one. Triangle keeps your whole medical file together, reads it with you in plain language, and helps you and your family decide what to ask next.
Start your 7-day free trial
Then $9 a month. Cancel anytime.
Every record in one place
Requested from your hospitals and clinics through the national networks. Add scans, pathology and anything on paper.
Read in plain words
Reports explained as they come in, with lab values you can follow before treatment, during a trial and after.
Ready for every appointment
Ask about your own file, and walk in with questions for your oncologist or the trial team.
Your people, in the loop
Share one profile with the family helping you, and with your doctors.
Members also get a deeper analysis of their records and any sequencing data, including clinical trials that may fit, reviewed by a licensed physician before they receive it.
How these trials work: what Phase 1 actually is · common questions Not clinical evidence.
Not sure whether you would qualify?
Would this trial apply to me?7-day free trial, then $9 a month. Cancel anytime.