TriangleDonor NK Cells + Temozolomide (NCT05588453)
Donor NK Cells + Temozolomide trial for Stage IV Melanoma With Brain Metastases (NCT05588453). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with stage four melanoma that has spread to the brain.
The idea: give natural killer cells, immune cells that can recognize and destroy cancer cells, from a universal donor. These cells are prepared so they can resist a signal called TGF beta that tumors use to switch immune cells off. They are given by vein with temozolomide, a chemotherapy pill.
The study looks for a safe dose and whether brain tumors shrink.
This phase 1 and 2 study plans 24 patients. At Ohio State University Comprehensive Cancer Center in Columbus, Kari Kendra leads it.
Public record; not medical advice.
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How these trials work: what Phase 1 actually is · common questions Not clinical evidence.