TriangleDonor NK Cells + Temozolomide (NCT05588453)
Donor NK Cells + Temozolomide trial for Stage IV Melanoma With Brain Metastases (NCT05588453). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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This trial is for adults with stage four melanoma that has spread to the brain.
The idea: give natural killer cells, immune cells that can recognize and destroy cancer cells, from a universal donor. These cells are prepared so they can resist a signal called TGF beta that tumors use to switch immune cells off. They are given by vein with temozolomide, a chemotherapy pill.
The study looks for a safe dose and whether brain tumors shrink.
This phase 1 and 2 study plans 24 patients. At Ohio State University Comprehensive Cancer Center in Columbus, Kari Kendra leads it.
Public record; not medical advice.
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