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Lifileucel (LN-144/LN-145)

LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, Dedifferentiated Liposarcoma, or Angiosarcoma

  • RegistryNCT05607095
  • PhasePhase 1
  • StatusRecruiting
  • ConditionUveal Melanoma
  • SponsorMemorial Sloan Kettering Cancer Center
How Lifileucel (LN-144/LN-145) works1 min

The drug

What is being tested.

Lifileucel (LN-144/LN-145) is an autologous Tumor Infiltrating Lymphocytes (TIL) cell therapy that utilizes a 22-day centralized GMP process. Lifileucel is infused as part of a treatment regimen that includes preparative NMA-LD, followed by one-time autologous TIL infusion, and a short course of high-dose IL-2.

The study

How the trial runs.

This is an open label study evaluating lifileucel (LN-144) in patients with metastatic uveal melanoma.

Live record on ClinicalTrials.gov →

Eligibility

Who the study is looking for.

  • Cohort 1: Must have a confirmed diagnosis of metastatic Uveal Melanoma.
  • o Patients will be eligible regardless of the number of prior systemic therapies received.
  • Cohort 2: Must have a confirmed diagnosis of unresectable or metastatic undifferentiated pleomorphic sarcoma (UPS) or dedifferentiated liposarcoma (DDLPS) that is refractory to at least 1 prior line of systemic therapy
  • Unresectable disease will be defined by an expert sarcoma surgical oncologist as either (a) low likelihood of obtaining an R0 resection or (b) unacceptable morbidity from a surgical procedure
  • Prior systemic therapy in the neoadjuvant or adjuvant setting will count has prior systemic therapy
  • Patients who refuse standard of care chemotherapy will be eligible

Inclusion criteria as written on the registry, trimmed. The full list, with exclusions, is on the live record.

For you, or someone you love

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Members also get a deeper analysis of their records and any sequencing data, including clinical trials that may fit, reviewed by a licensed physician before they receive it.

How these trials work: what Phase 1 actually is · common questions Not clinical evidence.

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