TriangleCAR.70/IL15-transduced CB-NK cells (NCT05092451)
CAR.70/IL15-transduced CB-NK cells trial for B-Cell Lymphoma (NCT05092451). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
CAR T cells have cured some blood cancers. But they must be built from each patient's own blood, over weeks, and a relapsed patient may not have weeks.
The idea: build the cells in advance, from umbilical cord blood, so they wait in the freezer.
Natural killer cells from donated cord blood are given a receptor for CD70, a protein on many leukemias, lymphomas, and myelomas but few healthy cells. They also carry a gene for interleukin-15, a survival signal, so they persist. In myeloma models, they kept working after the usual target, BCMA, disappeared.
MD Anderson, with David Marin, gives one dose after chemotherapy makes room, to patients from age twelve whose cancer carries CD70. Safety first. Public record; not medical advice.
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