TriangleB7-H3.CD28Z.CART (NCT07390539)
B7-H3.CD28Z.CART trial for Central Nervous System Neoplasms (NCT07390539). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
Medulloblastoma and its cousins are the most common malignant brain tumors of childhood. When they return after treatment, there is no reliable cure.
The idea: send engineered immune cells first through the blood, then directly into the fluid around the brain.
Most of these tumors carry a surface protein called B7-H3. A child's own T cells are fitted with a receptor for it, and after chemotherapy makes room, given once by vein. Then, through a small reservoir under the scalp, further doses go into the ventricles every four weeks, up to eight, reaching tumor spread along the brain and spine.
A new trial, at Dana-Farber and Boston Children's, ages two to twenty-one. Susan Chi leads it. Safety first. Public record; not medical advice.
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How these trials work: what Phase 1 actually is · common questions Not clinical evidence.