TriangleB7-H3.CD28Z.CART (NCT07390539)
B7-H3.CD28Z.CART trial for Central Nervous System Neoplasms (NCT07390539). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Medulloblastoma and its cousins are the most common malignant brain tumors of childhood. When they return after treatment, there is no reliable cure.
The idea: send engineered immune cells first through the blood, then directly into the fluid around the brain.
Most of these tumors carry a surface protein called B7-H3. A child's own T cells are fitted with a receptor for it, and after chemotherapy makes room, given once by vein. Then, through a small reservoir under the scalp, further doses go into the ventricles every four weeks, up to eight, reaching tumor spread along the brain and spine.
A new trial, at Dana-Farber and Boston Children's, ages two to twenty-one. Susan Chi leads it. Safety first. Public record; not medical advice.
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