TriangleVISTA (NCT03740256)
VISTA trial for Bladder Cancer (NCT03740256). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Many solid tumors, in breast, stomach, bladder, head and neck, carry a growth receptor called HER2. Anti-HER2 drugs help, but advanced disease outruns them, and CAR T cells alone rarely get a foothold in solid tumors.
The idea: light a fire inside the tumor first, then send in the cells.
At Baylor St. Luke's in Houston, a virus engineered to infect cancer cells, CAdVEC, is injected directly into one reachable tumor. As it replicates, it inflames the site and recruits immune cells. Three days later, the patient's own T cells, given a receptor for HER2, are infused and drawn toward that inflamed tumor and beyond.
VISTA is a first study in people, across HER2-positive cancers. Shalini Makawita leads it. Public record; not medical advice.
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