TriangleTrabedersen (NCT06579196)
Trabedersen trial for Non-small Cell Lung Cancer (NCT06579196). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Lung cancer is America's leading cancer killer. When tumors carry the marker PD-L1, treatment now starts with pembrolizumab, which takes the brakes off the immune system. It helps some; most tumors find a way through.
One way is a molecule called TGF-beta two, which tumors pour out to tell immune cells to stand down.
The idea: cut off that molecule while pembrolizumab does its work.
Trabedersen is a short strand of synthetic DNA that binds the instructions for TGF-beta two so they cannot be read. It has been tried before, in pancreatic cancer and glioma.
This trial, at the University of Nebraska with Omar Abughanimeh, gives it by infusion with pembrolizumab, and asks first what dose is safe. Public record; not medical advice.
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