TriangleTNhYP218 CAR T Cells (NCT06885697)
TNhYP218 CAR T Cells trial for Mesothelioma (NCT06885697). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Mesothelioma grows in the lining of the chest, usually decades after breathing asbestos. Most people live one to two years after diagnosis.
Its cells are coated in a protein called mesothelin, which also marks many pancreatic, ovarian, and lung cancers. CAR T cells aimed at mesothelin have mostly fallen short.
The idea: grip the target closer to the cell, with younger cells.
Earlier receptors grabbed mesothelin at its far tip. This one binds near the membrane, and in the lab that meant more killing and longer-lived T cells. The cells are also drawn from the youngest, stem-like T cells, slower to exhaust.
Raffit Hassan leads it at the NIH Clinical Center, in adults whose tumors carry mesothelin. Safety first. Public record; not medical advice.
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