TriangleCAR.70 NK Cells (NCT07444632)
CAR.70 NK Cells trial for Relapsed or Refractory Lymphomas and B-ALL (NCT07444632). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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This trial is for adults with lymphomas or B cell acute lymphoblastic leukemia that have come back or not responded to treatment.
The idea: natural killer cells from donated umbilical cord blood are engineered with a CAR that targets CD70, given interleukin 15 to help them last, and edited so they ignore a suppressive signal called TGF beta. After short chemotherapy, the cells are given by vein.
The study looks at safety.
This phase 1 study plans 60 patients. At MD Anderson Cancer Center in Houston, Yago Nieto leads it.
Public record; not medical advice.
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