TriangleStudy of B7-H3-Specific CAR T Cell… (NCT04185038)
Study of B7-H3-Specific CAR T Cell Locore… trial for Central Nervous System Tumor (NCT04185038). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Diffuse midline glioma grows in a child's brainstem, where no surgeon can cut. Radiation buys time; half of these children live under a year.
The idea: teach the child's own immune cells to find the tumor, and deliver them straight into the brain.
T cells from the child's blood are fitted with a receptor for B7-H3, a marker most of these tumors carry. Then, instead of a vein, they go through a small catheter into the fluid around the brain, dose after dose, over months.
In the first twenty-one children, repeated doses were tolerable, and three were alive more than three and a half years after diagnosis.
BrainChild-03, at Seattle Children's, now asks the same question in more tumors. Public record; not medical advice.
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