TrianglePNOC020 (NCT04573140)
PNOC020 trial for Adult Glioblastoma (NCT04573140). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Glioblastoma hides from the immune system. Few immune cells go in, and those that do fall quiet. Vaccines have mostly failed to wake anything.
The idea: make the body think the tumor is a virus.
After surgery, the patient's own tumor is ground up and its messenger RNA copied, wrapped in layers of fat particles like an onion, and infused into a vein. To the immune system, foreign RNA looks like an infection. Alarms ring, aimed at the tumor's own genes.
In the first four adults, immune activity surged within two days. In pet dogs with brain tumors, survival lengthened.
PNOC020, at Florida and Children's National with Lindsay Kilburn, now tests it in children and adults, safety first. Public record; not medical advice.
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