TriangleOncolytic Adenovirus Ad5-DNX-2401 (NCT03896568)
Oncolytic Adenovirus Ad5-DNX-2401 trial for Recurrent Glioblastoma (NCT03896568). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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DNX-2401, a rebuilt cold virus that multiplies only in tumor cells, has been injected into glioblastomas for over a decade; a few patients lived for years. The limit is delivery: a needle reaches one spot; glioblastoma is everywhere.
The idea: hire cells that seek out tumors, and let them carry the virus in.
Mesenchymal stem cells from donor bone marrow home naturally to inflamed tissue, which describes a tumor exactly. They are loaded with the virus. Then, through a catheter threaded from the groin to the brain's arteries, they ride the tumor's own blood supply and unload the virus where they land.
This trial, at MD Anderson with Frederick Lang, is the first in people, finding a safe dose. Public record; not medical advice.
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