TriangleNK Cells (NCT07579208)
NK Cells trial for Recurrent Glioblastoma (NCT07579208). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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When glioblastoma comes back, engineered immune cells are among the few new ideas, but two things hold them back: the tumor switches them off, and no one knows the best way in.
The idea: build a natural killer cell that resists the tumor's defenses, and test three routes head to head.
At MD Anderson, donor natural killer cells receive receptors for two glioblastoma markers, IL13Rα2 and EGFRvIII. They secrete interleukin-21 to sustain themselves, and two genes are deleted, the TGF-beta receptor and the steroid receptor, so neither the tumor nor patients' steroids can quiet them. Cells go into the tumor, the ventricles, or an artery; tissue is studied afterward to see which route works best.
Chibawanye Ene leads it. Public record; not medical advice.
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