TriangleNeural Stem Cells-expressing… (NCT05139056)
Neural Stem Cells-expressing CRAd-S-pk7 trial for Currently Only Enrolling Glioblastoma Patients at First Recurrence (NCT05139056). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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When glioblastoma comes back, most patients have under a year. Viruses engineered to kill cancer cells show promise, but spread poorly through brain tissue.
The idea: load the virus into cells that naturally migrate toward tumors, and let them carry it.
Neural stem cells home to gliomas. At City of Hope, banked cells are loaded with an adenovirus built to replicate only in cancer cells. During surgery to remove the recurrent tumor, the first dose goes into the cavity walls, where invading cells remain. Three more doses follow through a catheter left in place, weekly or every two weeks.
Enrolling glioblastoma at first recurrence at City of Hope, Stanford, Northwestern, and Wake Forest. Jana Portnow leads it. Public record; not medical advice.
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