TriangleIMPACT (NCT07148050)
IMPACT trial for Solid Tumor (Excluding CNS) (NCT07148050). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Some childhood solid tumors, liver cancers, Wilms tumor, rhabdomyosarcoma, share a protein called glypican-3. When they return, few options remain.
The idea: aim engineered T cells at that protein, give them their own fuel, and build in an off switch.
At Seattle Children's, a child's T cells receive a receptor for glypican-3 together with genes for interleukin-15 and interleukin-21, signals that help them persist inside a solid tumor, where CAR T cells usually fade. In the lab, that combination killed tumor cells better than the receptor alone. A safety gene lets doctors eliminate the cells with a drug if side effects demand it.
IMPACT is an early safety study, ages one to twenty-six. Michelle Choe leads it. Public record; not medical advice.
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