TriangleIMPACT (NCT06193759)
IMPACT trial for Medulloblastoma, Childhood (NCT06193759). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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The youngest children with brain tumors face a hard trade: radiation damages a growing brain, so doctors use intensive chemotherapy instead, and many relapse anyway.
The idea: after standard treatment, send in T cells trained on that child's own tumor.
At Children's National, a piece of the tumor removed at surgery is sequenced and its proteins read to find markers unique to that cancer. The child's T cells are then grown in the lab against several of those markers at once, without gene editing, and infused once therapy is complete.
An early safety study, for children under five with embryonal tumors, and recurrent ependymoma up to age thirty.
Brian Rood leads IMPACT in Washington. Public record; not medical advice.
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