TriangleCAR T Cells After Lymphodepletion… (NCT04510051)
CAR T Cells After Lymphodepletion for the… trial for Malignant Brain Neoplasm (NCT04510051). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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When a child's brain tumor comes back after surgery, radiation, and chemotherapy, there is usually nothing standard left.
The idea: borrow a treatment that has already done something remarkable in adults.
Many brain tumors carry a surface protein called IL13 receptor alpha 2, which healthy brain does not. City of Hope built T cells with a receptor for it. Given to adults with recurrent glioblastoma, into the fluid around the brain, the cells were safe, and in one man with tumors through his brain and spine, every tumor disappeared for seven months.
This trial brings those cells to children and young adults, aged four to twenty-five, weekly for up to four weeks. Leo Wang leads it. Safety first. Public record; not medical advice.
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