TriangleGC511B CAR-T Cell (NCT07249879)
GC511B CAR-T Cell trial for Relapsed/Refractory Small Cell Lung Cancer (NCT07249879). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Small cell lung cancer responds to chemotherapy, then almost always returns within months, and second-line options are weak.
The idea: a CAR T cell for a target that small cell lung cancer displays and normal adult tissue mostly hides.
That target is DLL3, a protein on the surface of most small cell lung cancers. At the Cancer Hospital of the Chinese Academy of Medical Sciences in Beijing, a patient's T cells are engineered with a receptor for DLL3 and returned in one infusion after conditioning chemotherapy. Doses rise cautiously, one patient at a time at first.
A first study in people, for relapsed or refractory disease whose tumor tests positive. Ning Li leads it. Public record; not medical advice.
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