TriangleFOLR1 CAR T-cells (NCT06609928)
FOLR1 CAR T-cells trial for Recurrent Childhood Acute Myeloid Leukemia (NCT06609928). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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One form of leukemia in babies and toddlers is unusually stubborn. It is driven by a fusion of two genes, and only about one child in four is still leukemia-free five years later.
The idea: that fusion switches on a protein healthy blood cells do not make, folate receptor alpha. A target on the cancer and almost nowhere else.
The child's own T cells are fitted with a receptor for it and grown into large numbers. Chemotherapy makes room, then the cells are infused back to hunt the leukemia.
Up to twelve children aged six and under, whose leukemia carries the marker and has come back, at Fred Hutch and Seattle Children's with Katherine Tarlock. First question: safety. Public record; not medical advice.
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