TriangleFGFR4-CAR T Cells (NCT06865664)
FGFR4-CAR T Cells trial for Rhabdomyosarcoma (NCT06865664). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Rhabdomyosarcoma is the most common soft tissue cancer in children. Low-risk disease is usually cured; when it comes back, fewer than one in five survive five years.
The idea: every rhabdomyosarcoma cell carries the same surface receptor, so aim engineered T cells at it.
That receptor is FGFR4. NCI researchers showed it sits on essentially all rhabdomyosarcomas and drives the most aggressive form, so it need not even be tested. A patient's T cells are collected, given a receptor for FGFR4, and returned in one infusion after four days of chemotherapy clears space.
A first dose-finding study, ages three to thirty-nine, after at least two prior treatments failed. Srivandana Akshintala leads it at the NIH Clinical Center. Public record; not medical advice.
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