TriangleCyclosporine (NCT03128034)
Cyclosporine trial for Acute Lymphoblastic Leukemia (NCT03128034). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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For high-risk acute leukemia, a donor transplant can cure, but only if conditioning clears enough disease, and stronger conditioning damages the whole body.
The idea: deliver radiation by antibody, straight to blood cells, using a particle that travels only a few cell widths.
At Fred Hutch in Seattle, an antibody against CD45, a marker on nearly all blood and leukemia cells, is labeled with astatine-211. Astatine emits alpha particles: heavy, intensely damaging, spent within a few cells' distance. Given a week before transplant, it targets the marrow and leukemia while sparing tissue beyond. Then fludarabine, low-dose total-body irradiation, and the donor's cells follow.
A dose-finding study in adults. Brenda Sandmaier leads it. Public record; not medical advice.
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