TriangleCIML NK (NCT04024761)
CIML NK trial for Acute Myeloid Leukemia (NCT04024761). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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A stem cell transplant is the last big move against acute myeloid leukemia. When the leukemia returns afterward, the usual answer is more of the donor's immune cells, and it rarely works.
The idea: send trained soldiers, not more of them.
Natural killer cells are the immune system's first responders. Taken from the transplant donor and bathed overnight in three signaling molecules, they gain something like memory: more alert, and they stay that way.
In the first six patients, the cells multiplied ten to fifty-fold inside the body and persisted for months; fever and low blood counts were the main side effects.
Dana-Farber and Boston Children's, with Susanne Baumeister and Roman Shapiro, now test them from age twelve up. Public record; not medical advice.
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