TriangleCD19/CD22-CAR-transduced T cells (NCT05442515)
CD19/CD22-CAR-transduced T cells trial for B-Non Hodgkin Lymphoma (NCT05442515). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Acute lymphoblastic leukemia is the most common childhood cancer, and nine in ten are cured. When it comes back, the odds fall below half.
CAR T cells aimed at a marker called CD19 rescued many of those children. But leukemia learns: some cells drop CD19 and slip away. Cells aimed at a second marker, CD22, get dodged the same way.
The idea: one T cell that watches both doors at once.
A child's own T cells receive one gene that builds both receptors. The National Cancer Institute's earlier two-target design was safe, but the cells faded quickly. This version is rebuilt to last.
Sara Silbert leads it at the NIH Clinical Center, for ages three to thirty-nine. Safety first. Public record; not medical advice.
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