TriangleCARE T cells (NCT04715191)
CARE T cells trial for Liver Cancer (NCT04715191). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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Some childhood solid tumors, liver cancer, rhabdomyosarcoma, Wilms tumor, share a surface protein called glypican-3. When those cancers return after surgery and chemotherapy, cures are rare.
The idea: aim engineered T cells at that shared protein, and arm them so they survive inside a solid tumor.
CAR T cells often stall in solid tumors, where they run out of support. At Texas Children's, a child's T cells receive a receptor for glypican-3 plus genes for two growth signals, interleukin-15 and interleukin-21, so the cells carry their own fuel. After three days of chemotherapy makes room, they are infused once.
A dose-finding trial, ages one to twenty-one, for tumors that test positive for the protein. David Steffin leads it. Public record; not medical advice.
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