TriangleAd5-yCD/mutTKSR39rep-ADP adenovirus (NCT05686798)
Ad5-yCD/mutTKSR39rep-ADP adenovirus trial for Malignant Glioma of Brain (NCT05686798). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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When glioblastoma grows back, surgeons can operate again, but cells remain in the cavity wall, and those regrow.
The idea: at the end of that second surgery, seed the cavity wall with a virus that turns tumor cells into their own chemotherapy factories.
It is a common-cold adenovirus, rebuilt to multiply only in cancer cells, carrying two extra genes. Each converts a harmless pill, an antifungal and an antiviral, into a drug that kills dividing cells where the virus is. Radiation follows; both drugs make tumor cells more sensitive to it.
Henry Ford Health in Detroit tested this virus in prostate cancer for years. This trial, with Tobias Walbert, brings it to the brain, asking what dose is safe. Public record; not medical advice.
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