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15.GPC3-CAR T cells (NCT06815432)

Cómo funcionan las células CAR T 15.GPC3NCT068154321 min

15.GPC3-CAR T cells trial for Glioblastoma Multiforme of Brain (NCT06815432). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

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Glioblastoma often returns after surgery, radiation, and chemotherapy. This study is for glioblastoma that has come back and carries a protein called GPC3.

The idea: give a patient's own immune cells a new target. T cells are taken from the blood, and genes are added so they recognize GPC3 and keep growing. The cells also carry a safety switch, so a drug can remove them if side effects appear.

During a surgery that is already planned, the cells are placed directly into the tumor area, one time. At Baylor St. Luke's in Houston, Ganesh Rao leads this early study. The first question is safety and dose.

Public record; not medical advice.

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