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Treatment of Liver Metastasis
Source: Rectal Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: February 12, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
Context: Treatment of Stage IV and Recurrent Rectal Cancer
Approximately 15% to 25% of patients with colorectal cancer will present with liver metastases at diagnosis, and another 25% to 50% will develop metachronous hepatic metastasis after resection of the primary tumor.[82-84] Although only a small proportion of patients with liver metastasis are candidates for surgical resection, advances in tumor ablation techniques and in both regional and systemic chemotherapy administration provide a number of treatment options. These include:
Surgery.
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Neoadjuvant chemotherapy for unresectable liver metastases.
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Local ablation for unresectable liver metastases.
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Adjuvant chemotherapy.
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Intra-arterial chemotherapy after liver resection.
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Preserved source evidence · Independent clinical review pending · Not medical advice