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Pleomorphic xanthoastrocytoma (PXA)–like

Source: Childhood Cancer Genomics (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 30, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

Context: Central Nervous System Tumors / Astrocytomas, Other Gliomas, and Glioneuronal/Neuronal Tumors / Molecular features of pediatric-type high-grade gliomas / Subgroups identified using DNA methylation patterns

Approximately 10% of pediatric high-grade gliomas have DNA methylation patterns that are PXA-like.[37] PXA-like cases commonly have BRAF V600E variants and a relatively favorable outcome (approximately 50% survival at 5 years).[10,48]

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Preserved source evidence · Independent clinical review pending · Not medical advice