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← Childhood Acute Lymphoblastic Leukemia

HEALTH PROFESSIONAL · SOURCE READING

Prognostic Factors After First Relapse of Childhood ALL

Source: Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 21, 2025 · Captured 2026-09-09.

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Context: Treatment of Relapsed Childhood ALL

The prognosis for a child with acute lymphoblastic leukemia (ALL) whose disease recurs depends on multiple factors.[1-15]; [16][Level of evidence C2]

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The following two important risk factors after first relapse of childhood ALL are key to determining prognosis and treatment approach:

Site of relapse.

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Time from diagnosis to relapse.

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Other prognostic factors include the following:

Patient characteristics (e.g., age and peripheral blast count at time of relapse).

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Risk group classification at initial diagnosis.

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Response to reinduction therapy.

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Cytogenetics/genomic alterations.

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Immunophenotype.

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Continue within this section

Site of relapse →Time from diagnosis to relapse →Patient characteristics →Risk group classification at initial diagnosis →Response to reinduction therapy →Cytogenetics/genomic alterations →Immunophenotype →

Publication references

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Preserved source evidence · Not medical advice