Site of relapse

Source: Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 21, 2025 · Captured 2026-09-09.

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Context: Treatment of Relapsed Childhood ALL / Prognostic Factors After First Relapse of Childhood ALL

Patients who have isolated extramedullary relapse generally fare better than those who have relapse involving the marrow. In some studies, patients with combined marrow/extramedullary relapse had a better prognosis than did those with a marrow only relapse. However, other studies have not confirmed this finding.[5,13,17] In one study by the Children's Oncology Group (COG), there was no difference in postrelapse survival between isolated marrow and combined marrow/extramedullary relapses in T-ALL or infant B-ALL. However, for noninfant patients with B-ALL, combined relapses were associated with a better outcome, compared with isolated marrow relapses.[15]

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