TriangleValproic Acid (VPA) (NCT07831369)
Valproic Acid (VPA) trial for Glioblastoma (NCT07831369). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults aged eighteen to ninety-eight with recurrent glioblastoma or IDH-mutated glioma. Glioblastoma requires prior temozolomide or radiation; IDH-mutated disease requires radiation and alkylating chemotherapy. MRI must show progression and a measurable enhancing lesion.
The idea: combine oral valproic acid and simvastatin with irinotecan infusions in twenty-one-day cycles. Irinotecan disrupts DNA copying. The study tests whether adding the other drugs produces tumor shrinkage; this benefit is unproven. Prior irinotecan excludes participation.
This phase 2 study plans 52 patients. Adam Cohen leads Inova's recruiting Fairfax site.
Public record; not medical advice.
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