TriangleBiospecimen Collection (NCT07734038)
Biospecimen Collection trial for Chronic Lymphocytic Leukemia (NCT07734038). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with CLL or SLL needing treatment. Participants are untreated or at least two years beyond one fixed-duration venetoclax-based treatment. Untreated patients cannot have del17p or TP53 mutations.
The idea: oral zanubrutinib blocks BTK growth signals; venetoclax blocks BCL-2 survival signals. Venetoclax starts in cycle four. Treatment lasts up to 15 cycles for untreated patients, or 27 for returning patients. Blood and marrow tests measure remaining cancer.
This phase 2 study plans 155 patients. Kerry Rogers leads at Ohio State in Columbus, the sole recruiting US site.
Public record; not medical advice.
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