FOLFOX (5-fluorouracil, Leucovorin,… (NCT07603375)

Name: FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) trial for Esophageal Adenocarcinoma (NCT07603375)
Uploaded: 2026-10-31T20:59:03.186Z
Duration: 1 min 18 s
Description: FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) trial for Esophageal Adenocarcinoma (NCT07603375). Who can join, how the treatment is intended to work, treatment groups and recruiting sites for NCT07603375.

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma: a one-minute explainerNCT076033751 min

FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) trial for Esophageal Adenocarcinoma (NCT07603375). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with newly diagnosed, nonmetastatic stage II through IVA adenocarcinoma of the thoracic esophagus or gastroesophageal junction. T4b tumors and prior treatment for this cancer are excluded.

The idea: combine carboplatin and paclitaxel with radiation, then give mFOLFOX6 or FLOT chemotherapy. Carboplatin damages DNA; paclitaxel blocks cell division. Researchers test whether added chemotherapy can control cancer and reduce surgery. Endoscopic biopsies assess complete response. Avoiding surgery is an aim, not an assured outcome.

This phase 2 study plans 60 patients. Manisha Palta leads Duke's recruiting Durham site.

Public record; not medical advice.

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