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Metronidazole (NCT06569368)

Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy: a one-minute explainerNCT065693681 min

Metronidazole trial for Rectal Adenocarcinoma (NCT06569368). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with locally advanced rectal adenocarcinoma planned for total neoadjuvant therapy. They must not have received chemotherapy for this tumor; unresectable disease is excluded.

The idea: test whether adding metronidazole reduces bacteria within rectal cancers. Randomized groups receive standard treatment alone or with oral metronidazole every eight hours for two weeks. Researchers assess bacteria, tumor response and safety. Both groups continue treatment selected by their doctor. Benefit remains unestablished.

This phase 2 study plans 60 patients. Michael White leads MD Anderson's recruiting Houston site.

Public record; not medical advice.

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