TriangleATG Combined with Tacrolimus and… (NCT06315309)
ATG Combined with Tacrolimus and Mini Methotrexate trial for GVHD,Acute (NCT06315309). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults aged 18–60 with qualifying acute leukemia, myelodysplastic syndrome, myeloproliferative disease or chronic myelomonocytic leukemia, receiving a first myeloablative transplant from a matched donor. Disease-specific remission and risk rules apply.
The idea: move most rabbit ATG earlier to reduce recipient immune cells while sparing donor cells. Patients receive tacrolimus and methotrexate. Conditioning uses fludarabine and busulfan, or cyclophosphamide and total-body radiation for lymphoblastic leukemia. Researchers measure graft-versus-host disease, relapse, survival and immune recovery.
This phase 2 study plans 29 patients. The University of Alabama sponsors its recruiting Birmingham site.
Public record; not medical advice.
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